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81.
Edyta Janik Marcin Niemcewicz Marcin Podogrocki Joanna Saluk-Bijak Michal Bijak 《International journal of molecular sciences》2021,22(11)
COVID-19 is a respiratory disease caused by newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease at first was identified in the city of Wuhan, China in December 2019. Being a human infectious disease, it causes high fever, cough, breathing problems. In some cases it can be fatal, especially in people with comorbidities like heart or kidney problems and diabetes. The current COVID-19 treatment is based on symptomatic therapy, so finding an appropriate drug against COVID-19 remains an immediate and crucial target for the global scientific community. Two main processes are thought to be responsible for the COVID-19 pathogenesis. In the early stages of infection, disease is determined mainly by virus replication. In the later stages of infection, by an excessive immune/inflammatory response, leading to tissue damage. Therefore, the main treatment options are antiviral and immunomodulatory/anti-inflammatory agents. Many clinical trials have been conducted concerning the use of various drugs in COVID-19 therapy, and many are still ongoing. The majority of trials examine drug reposition (repurposing), which seems to be a good and effective option. Many drugs have been repurposed in COVID-19 therapy including remdesivir, favipiravir, tocilizumab and baricitinib. The aim of this review is to highlight (based on existing and accessible clinical evidence on ongoing trials) the current and available promising drugs for COVID-19 and outline their characteristics. 相似文献
82.
83.
This paper presents an approach to the modelling of transient thermal states in electronic circuits using an analytical solution of the heat equation. Fully three-dimensional analytical time dependent solutions are determined with the help of Green's functions. The solution method is illustrated in detail on a practical example, where the results of transient thermal simulations of a real hybrid circuit are compared with infrared measurements. 相似文献
84.
Marcin Janicki Marcin Daniel Michal Szermer Andrzej Napieralski 《Microelectronics Journal》2004,35(10):831-840
The proper design and simulation of modern electronic microsystems oriented towards environment monitoring requires accurate models of various ambient sensors. In particular, this paper presents a comprehensive model of an ion sensitive field effect transistor (ISFET). The model can be employed straightforwardly for simulations at device, circuit or system level.First, the model was validated with electrical measurements and simulations of real structures performed for different ion concentration and temperature values. Then, the ISFET sensor model was employed for mixed-signal simulations in VHDL-AMS, when the analysis of a microsystem consisting of the ISFET sensor and a sigma-delta analogue-to-digital converter was carried out. Additionally, the presence of other ions than hydrogen in the measured solution was also taken into account in the simulations. 相似文献
85.
Synthesis of Novel Phosphonic‐Type Activity‐Based Probes for Neutrophil Serine Proteases and Their Application in Spleen Lysates of Different Organisms 下载免费PDF全文
Dr. Renata Grzywa Dr. Ewa Burchacka Maria Łęcka Dr. Łukasz Winiarski Maciej Walczak Agnieszka Łupicka‐Słowik Dr. Magdalena Wysocka Prof. Timo Burster Dr. Kamila Bobrek Dr. Keri Csencsits‐Smith Prof. Adam Lesner Dr. Marcin Sieńczyk 《Chembiochem : a European journal of chemical biology》2014,15(17):2605-2612
Neutrophils are a type of granulocyte important in the “first line of defense” of the innate immune system. Upon activation, they facilitate the destruction of invading microorganisms by the production of superoxide radicals, as well as the release of the enzymatic contents of their lysozymes. These enzymes include specific serine proteases: cathepsin G, neutrophil elastase, proteinase 3, as well as the recently discovered neutrophil serine protease 4 (NSP4). Under normal conditions, the proteolytic activity of neutrophil proteases is tightly regulated by endogenous serpins; however, this mechanism can be subverted during tissue stress, thereby resulting in the uncontrolled activity of serine proteases, which induce chronic inflammation and subsequent pathology. Herein, we describe the development of low‐molecular‐weight activity‐based probes that specifically target the active sites of neutrophil proteases. 相似文献
86.
ABSTRACTSuperheaters are high-temperature cross-flow heat exchangers. Steam flows inside the tubes, and the flue gas outside in a direction perpendicular to the axes of the tubes. However, they differ very substantially from the other heat exchangers operating at low temperatures. Superheaters are characterized by complex flow system and high tube walls temperature. Superheaters are among the most exposed to damaging pressure elements of steam boilers. Damage to the superheater causes about 40% of emergency shutdowns of boilers. The paper presents the boiler superheater model with distributed parameters, which is used to determine on-line the degree of superheater fouling by ash. 相似文献
87.
Marcin ?roda Katarzyna Cholewa-KowalskaMarek Ró?ański Marek Nocuń 《Optical Materials》2011,33(3):397-401
Glasses of different matrix (phosphate, borate, silicate and lead-silicate) were studied for their optical properties. The effect of Er dopant on transmittance and luminescence properties was presented. The significant “red shift” and “blue shift” of UV edge absorption were discussed based on the changes in the framework of the borate and phosphate glasses, respectively. It was showed that the integral intensity of the two main optical absorption transitions monotonically increases with the order: phosphate < borate < silicate < lead-silicate. Ellipsometric measurement was applied to obtain the refractive index of the glasses. The correlation between the shift of edge absorption and the change of refractive index was presented. Effect of glassy matrix on luminescence of Er3+ was discussed. 相似文献
88.
89.
In this paper we present results of detailed spectroscopic studies of Tb3+ luminescence from BaF2:0.075 mol% Tb performed at Superlumi station of Hasylab, DESY, Hamburg and at Institute of Physics, N. Copernicus University, Torun, Poland (IF UMK Torun).We have measured UV/VUV excitation spectra of the dominant blue Tb3+ luminescence and emission spectra under excitation into various bands found from the excitation spectra. The excitation spectra are dominated by the two well known broad bands due to the parity and spin-allowed (SA) 4f8 → 4f75d transitions. The higher energy triple t-band and unresolved single e-band at lower energies are widely separated (10 Dq about 16,500 cm−1) reflecting the single d-electron energy in the high symmetry cubic crystal field with a relatively low contribution from the low symmetry component.In addition to these bands we have also detected a number of weaker bands at lower energy sides of both dominant SA bands. While the structured band with components at 252.8, 252.3, 250.4 and 248.4 nm clearly corresponds to the SF (spin-forbidden) band found earlier in LiYF4:Tb, the bands at 183, 178 and 172 nm have been never, to the best of our knowledge, reported before. We present arguments that these new bands are the SF counterparts of the triple SA t-band at about 158 nm. The d-f exchange energies for d(e) and d(t) electrons are different at 7779 and 8245 cm−1, respectively.Although the energy levels corresponding to the identified high and low spin (HS and LS) states of the 4f75d configuration are, in BaF2, well separated, there are no SA nor SF transitions generating d-f emission in BaF2:Tb. This is because the numerous 4f8 energy levels intercept the excitation energy from 4f75d levels leading to the well known blue and green Tb3+ 4f8 emissions. 相似文献
90.
Kocan Marcin Wagner Lothar Rack H. J. 《Journal of Materials Engineering and Performance》2005,14(6):765-772
This investigation examined the role of microstructure and surface finish on the high cycle fatigue (HCF) performance of TIMETAL
LCB (Ti-6.8Mo-4.5Fe-1.5Al). The as-received microstructure of LCB consisted of elongated β grains with a semicontinuous grain
boundary α layer. In contrast, a fine equiaxed β + spheroidized α LCB microstructure was achieved by hot swaging and solution
(recrystallization) anneal. The latter modification of the prior β grain structure, together with the size, morphology, and
distribution of the primary α phase, resulted in a significant enhancement in the tensile and HCF properties. Furthermore,
prestraining (PS), as would be expected during the fabrication of an automotive coil spring, and prior to aging for 30 min
at temperatures between 500 and 550 °C, led to additional increases in tensile strength. In contrast, the HCF performance
was always reduced when PS prior to aging was included in the overall processing procedure. Finally, shot-peening and roller-burnishing
both resulted in an increased fatigue life in the finite life regimen; however, significant reductions in the 107 cycle fatigue strengths were observed when these procedures were used. These observations have been explained by including
the effect of process-induced residual tensile stresses in the fatigue analysis, resulting in subsurface fatigue crack nucleation.
This paper was presented at the Beta Titanium Alloys of the 00’s Symposium sponsored by the Titanium Committee of TMS, held
during the 2005 TMS Annual Meeting & Exhibition, February 13–16, 2005 in San Francisco, CA. 相似文献